Immunogenic peptide fragment aiming at human angiopoietin-like protein 3 as well as vector vaccine and application thereof

The invention relates to the technical field of medical biology, in particular to an immunogenic peptide fragment aiming at human angiopoietin-like protein 3 as well as a vector vaccine and application of the immunogenic peptide fragment. The amino acid sequence of the immunogenic peptide fragment aiming at the human angiopoietin-like protein 3 is KPRAPRTT, and is as shown in SEQ ID No. 1. The immunogenic vector vaccine is prepared by coupling an ANGPTL3 immunogenic peptide fragment and a vector. The vector is a Qbeta-2aa bacteriophage virus-like particle protein. The immunogenic vector vaccine aiming at the human ANGPTL3 disclosed by the invention can be used for effectively reducing hyperlipidemia and inhibiting atherosclerosis. 本发明涉及医学生物技术领域，具体涉及一种针对人血管生成素样蛋白3的免疫原性肽段及其载体疫苗和用途；所述针对人血管生成素样蛋白3的免疫原性肽段的氨基酸序列为KPRAPRTT，如SEQ ID No.1所示。所述免疫原性载体疫苗由ANGPTL3免疫原性肽段与载体偶联制备而成。所述载体为Qβ-2aa噬菌体病毒样颗粒蛋白。本发明针对人ANGPTL3的免疫原性载体疫苗能有效降低高脂血症和抑制动脉粥样硬化。