Synthesis process of N-t-butyloxycarbonyl-L-glutamic acid dimethyl ester

The invention relates to the technical field of synthesis of drug intermediates, in particular to a synthesis process of N-t-butyloxycarbonyl-L-glutamic acid dimethyl ester. The method comprises the following steps: esterifying L-glutamic acid serving as a raw material with methanol to obtain an esterified product; and carrying out condensation on the esterified product and Boc anhydride to obtain a target product. The synthesis process of N-t-butyloxycarbonyl-L-glutamic acid dimethyl ester provided by the invention has the characteristics of cheap and easily available initial raw materials, high production yield, safe and controllable process and easy operation. 本发明涉及药物中间体的合成技术领域，具体涉及一种N-叔丁氧羰基-L-谷氨酸二甲酯的合成工艺。它是以L-谷氨酸为原料，与甲醇酯化得到酯化物；酯化物再与Boc酸酐缩合得到目标产物。本发明提供的N-叔丁氧羰基-L-谷氨酸二甲酯的合成工艺具有起始原料价廉、易得，生产收率高，工艺安全、可控、易操作的特点。