Ursodeoxycholic acid sustained release preparation and preparation method thereof

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an ursodesoxycholic acid sustained release preparation and a preparation method thereof. Aiming at the defects that the absorptivity is low, the ursodesoxycholic acid is quickly released in intestinal tracts, high concentration is formed, absorption is hindered and gastrointestinal tract disorder is caused, the ursodesoxycholic acid is adsorbed by taking porous silicon dioxide nanoparticles as a carrier, and a drug-loaded biological membrane is synthesized by collagen, chitosan and a cross-linking agent to coat the porous silicon dioxide nanoparticles, so that the ursodesoxycholic acid sustained-release preparation is prepared. The prepared ursodesoxycholic acid sustained-release nanoparticles can regulate and control the release rate of ursodesoxycholic acid, and have extremely high encapsulation efficiency. 本发明属于药物制剂技术领域，具体为一种熊去氧胆酸缓释制剂及其制备方法。本发明针对吸收率较低，在肠道内迅速释放，形成较高浓度，还会阻碍吸收，引起胃肠道紊乱的缺陷，以多孔二氧化硅纳米颗粒为载体吸附熊去