Isoniazide inhalation solution as well as preparation method and application thereof

The invention relates to an isoniazide inhalation solution as well as a preparation method and application thereof. The inhalation solution comprises isoniazide, an osmotic pressure regulator, a pH regulator and water, wherein the volume/weight ratio of the pH regulator to the isoniazide is 3%-5%, and the volume/weight ratio of the water to the isoniazide is 10-20. The inhaled preparation has the advantages that the inhaled preparation directly acts on the lung through mouth and nose inhalation, can gather into higher concentration in the lung and enter a breathing and blood circulation system, so that the purpose of systemic medication can be achieved, and the inhaled preparation greatly reduces the metabolic process of the liver and kidney to the medicine and greatly reduces the liver and kidney injury to a patient. 本发明涉及一种异烟肼吸入溶液剂及其制备方法和应用，该吸入溶液制剂的组成包括异烟肼、渗透压调节剂、PH调节剂及水；其中PH调节剂和异烟肼按体积/重量比为3％～5％、水和异烟肼按体积/重量比为10～20。本发明具有的优点是通过由口鼻吸入直接作用在肺部，可在肺部聚集成较高浓度，进入呼吸和血液循环系统，从而可达到全身用药的目的，并且吸入制剂大大减少了由肝肾对药物的代谢过程，极大降低了对患者的肝