N-linked macrocyclic 4-(pyrazol-5-yl)-indole derivatives as MCL-1 inhibitors

N-linked macrocyclic 4-(pyrazol-5-yl)-indole derivatives as MCL-1 inhibitors

The present invention relates to agents useful in the treatment and/or prophylaxis of subjects, pharmaceutical compositions comprising such compounds, and their use as MCL-1 inhibitors useful in the treatment of diseases such as cancer. 本发明涉及可用于受试者的治疗和/或预防的药剂，包含此类化合物的药物组合物，以及它们作为可用于治疗疾病诸如癌症的MCL-1抑制剂...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ROMBOUTS F. J. R, PESCHIULI ALESSANDRO, WIRTEL ARNEO
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to agents useful in the treatment and/or prophylaxis of subjects, pharmaceutical compositions comprising such compounds, and their use as MCL-1 inhibitors useful in the treatment of diseases such as cancer. 本发明涉及可用于受试者的治疗和/或预防的药剂，包含此类化合物的药物组合物，以及它们作为可用于治疗疾病诸如癌症的MCL-1抑制剂的用途。