Method of treatment of corticosteroid induced osteopenia

甲状旁腺素PTH、甲状旁腺素相关肽PTHrp、和PTH和PTHrp的具有生理活性的截短形式同系物和类似物的合成多肽类似物和它们药学上认可的盐可用于预防和治疗哺乳动物由皮质甾类诱发的骨质减少，其中所述合成多肽类似物的氨基酸残基(22-31)形成两亲α-螺旋，所述的残基选自按以下顺序排列的亲水性氨基酸(Haa)和亲脂性氨基酸(Laa)：Haa(Laa Laa Haa Haa)#-[2]Laa。 Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, an...

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1. Verfasser:	B.H. VICKERY
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Zusammenfassung:	甲状旁腺素PTH、甲状旁腺素相关肽PTHrp、和PTH和PTHrp的具有生理活性的截短形式同系物和类似物的合成多肽类似物和它们药学上认可的盐可用于预防和治疗哺乳动物由皮质甾类诱发的骨质减少，其中所述合成多肽类似物的氨基酸残基(22-31)形成两亲α-螺旋，所述的残基选自按以下顺序排列的亲水性氨基酸(Haa)和亲脂性氨基酸(Laa)：Haa(Laa Laa Haa Haa)#-[2]Laa。 Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic alpha -helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence:Haa(Laa Laa Haa Haa)2 Laaand their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of corticosteroid induced osteopenia in mammals.