Antibacterial peptide RMR26 as well as preparation method and application thereof

The invention discloses an antibacterial peptide RMR26 as well as a preparation method and application of the antibacterial peptide RMR26. The amino acid sequence of the antibacterial peptide RMR26 is as follows: Arg-Ser-Thr-Lys-Ala-Gly-Val-Ile-Phe-Pro-Val-Gly-Arg-Met-Leu-Arg-Tyr-Ile-Lys-Arg-Gly-Leu-Pro-Lys-Tyr-Arg. The antibacterial peptide RMR26 can be synthesized by a solid-phase chemical method. The antibacterial peptide RMR26 obtained by the invention has relatively strong antibacterial activity, relatively weak hemolytic activity and relatively low cytotoxicity, can be used as an antibiotic substitute, and is applied to pharmaceutical antibacterial preparations, food preservatives, feed additives in the breeding industry, cosmetic preservatives and the like. 本发明公开了一种抗菌肽RMR26及其制备方法和应用，其氨基酸序列为Arg-Ser-Thr-Lys-Ala-Gly-Val-Ile-Phe-Pro-Val-Gly-Arg-Met-Leu-Arg-Tyr-Ile-Lys-Arg-Gly-Leu-Pro-Lys-Tyr-Arg。抗菌肽RMR26可以用固相化学法合成。本发明所得到的抗菌肽RMR26具有较强的抑菌活性、较弱的溶血活性和较低的细胞毒性，可作为抗生素替代品使用，应用于药品抗菌制剂、食品防腐剂、养殖业饲料添加剂和化妆品防腐剂等。