Glycyrrhetinic acid-dodecane-cholesterol compound as well as synthesis method and application thereof

The invention discloses a glycyrrhetinic acid-dodecane-cholesterol compound as well as a synthesis method and application thereof, and the synthesis method of the glycyrrhetinic acid-dodecane-cholesterol compound comprises the following steps: S1, mixing glycyrrhetinic acid, 1, 12-diaminododecane, an acid amine condensation reagent, an acid-binding agent 1 and a solvent 1 for reaction to obtain a compound (II); s2, enabling the compound (II) to react with cholesterol succinic acid monoester acyl chloride to obtain a glycyrrhetinic acid-dodecane-cholesterol compound; the glycyrrhetinic acid-dodecane-cholesterol compound disclosed by the invention is simple in synthesis method and mild in reaction condition and has anti-hepatoma activity. 本发明公开了一种甘草次酸-十二烷-胆固醇化合物及其合成方法和应用，甘草次酸-十二烷-胆固醇化合物的合成方法包括：S1：将甘草次酸、1,12-二氨基十二烷、酸胺缩合试剂、缚酸剂1和溶剂1混合反应得到化合物(II)；S2：使化合物(II)和胆固醇琥珀酸单酯酰氯反应，得到甘草次酸-十二烷-胆固醇化合物；本发明的甘草次酸-十二烷-胆固醇化合物合成方法简单，反应条件温且具有抗肝癌活性。