Preparation method of beta-fluoroalkyl-beta-amino vinyl ketone compound

The invention discloses a preparation method of a beta-fluoroalkyl-beta-amino vinyl ketone compound, which is characterized in that amidine hydrochloride and a hydroxyl-containing allyl fluorine compound are subjected to defluorination reaction in a solvent under the action of ammonium carbonate and water to obtain the beta-fluoroalkyl-beta-amino vinyl ketone compound. The method has the characteristics of mild reaction conditions, good functional group tolerance, simple post-treatment, green steps, low pollution, high economic benefits and the like. 本发明公开了一种β-氟烷基-β-氨基乙烯基酮化合物的制备方法，将脒类盐酸盐和含羟基的烯丙基氟化合物在碳酸铵和水的作用下，于溶剂中进行脱氟反应，得到β-氟烷基-β-氨基乙烯基酮化合物。本发明反应条件温和，官能团耐受性好，具有后处理简单、步骤绿色、污染低、经济效益高等特点。