Preparation and application of silk fibroin peptide-naringenin nanofiber

The invention discloses preparation and application of silk fibroin peptide-naringenin nanofibers. The silk fibroin peptide-naringenin nanofibers are formed by interaction and self-assembly of hydrophobic drug naringenin and silk fibroin peptide. According to the preparation and the application of the silk fibroin peptide-naringenin nanofiber with the structure, the prepared nanoparticles are found to have a kidney protection effect through experiments, can obviously weaken the renal injury effect induced by cis-platinum, and are high in drug loading capacity, strong in transportation carrier functionality and high in stability, the application of naringenin is increased, and the application range of the silk fibroin peptide-naringenin nanofiber is widened. The preparation process is simple to operate, equipment is simple, large-scale production is easy, and the application of naringenin is increased. 本发明公开了一种丝素蛋白肽-柚皮素纳米纤维的制备及其应用，由疏水性药物柚皮素与丝素蛋白肽相互作用自组装而成。本发明采用上述结构的一种丝素蛋白肽-柚皮素纳米纤维的制备及其应用，制得的纳米粒子通过实验发现具有肾保护作用，可