Neutrophil progenitor cells and related methods and uses

There is provided a method of identifying a neutrophil progenitor cell, the method comprising: determining the expression of at least one biomarker in the cell, the biomarker being selected from the group consisting of: CD71, LOX-1, CD164, CD112, CD181, TACSTD2, CD11b, and CD49d. In various embodiments, a cell is identified as a neutrophil progenitor cell when it is determined that the cell has at least one of the following expression profiles: CD71 high/+, LOX-1 medium/low/-, CD164 high/+, CD112 high/+, CD181 medium/low/-, TACSTD2 high/+, CD11b low/-, and/or CD49d medium/high/+. Also disclosed are a method of sorting and/or isolating neutrophil progenitor cells from a population of cells, a composition enriched in neutrophil progenitor cells, and related uses and methods. 提供了一种鉴定嗜中性粒细胞祖细胞的方法，所述方法包括：测定细胞中至少一种生物标志物的表达，所述生物标志物选自下组：CD71、LOX-1、CD164、CD112、CD181、TACSTD2、CD11b和CD49d。在多个实施方案中，当确定细胞具有下列表达谱的至少一种时，将该细胞鉴定为嗜中性粒细胞祖细胞：CD71高/+、LOX-1中/低/-、CD164高/+、CD112高/+、CD181中/低/-、TACSTD2高/+、CD11b低/-和/或CD49d中/高/+。还公开了一种从细