Human interleukin-2 conjugates biased to interleukin-2 receptor beta gamma c dimers and conjugated to non-peptide water-soluble polymers

The present invention describes interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions biased to bind IL-2 receptor beta gamma c dimer relative to bind IL-2 receptor alpha beta gamma c trimer and an unnatural amino acid conjugated to a water soluble polymer at or ne...

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Hauptverfasser:	BAUMANN EBERHARD, LI XIAOFAN, YANG JUNHAO, SOLIS WILLIAM, YAM ALISON, LIN SUSHEN, WILHELM ANDREAS, ABRAHAM CHRISTOPHER, STAFFORD ROBERT, YIN GANG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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