Method for increasing yield of polythiodiketopiperazine compound emerin

The invention discloses a method for improving the yield of a polythiodiketopiperazine compound emerin, which comprises the following steps: adding glutathione into a fermentation medium, sterilizing the fermentation medium, inoculating a microbial seed solution, and fermenting to obtain the compound emerin, wherein 0.001 to 99.999 g of glutathione is added into each 100 g of the fermentation culture medium; the mass volume ratio of the fermentation culture medium to the seed solution is (1: 0.001)-(1: 99.999) g/mL. According to the method disclosed by the invention, the yield of the emerin is remarkably improved, the fermentation time is saved, the efficiency of producing the emerin is improved, the production cost is reduced, and the method is suitable for large-scale industrial production. 本发明公开了一种提高多硫代二酮哌嗪类化合物emestrin产量的方法，包括：往发酵培养基中加入谷胱甘肽，发酵培养基灭菌，接种微生物的种子液，发酵，得到化合物emestrin；其中，每100g发酵培养基中加入谷胱甘肽0.001～99.999g；所述的发酵培养基和种子液的质量体积比1:0.001～1:99.999g/mL。本发明方法显著提高了emestrin产量，节省了发酵时间，提高了生产emestrin的效率，降低了生产成本，适合大规模工