Hydantoin compound and medical application thereof

The invention discloses a hydantoin compound and medical application thereof, and provides the hydantoin compound shown as a formula (I) or pharmaceutically acceptable salt thereof, and the compound has a strong excitation effect on PPAR alpha and PPAR delta, has good selectivity on PPAR gamma, and has good pharmacokinetic properties. Therefore, the compounds or pharmaceutically acceptable salts, prodrugs, deuterated compounds or solvates thereof can be applied to preparation of PPAR alpha/delta dual agonists for preventing or treating PPAR alpha and/or PPAR delta mediated diseases. 本发明公开了海因类化合物及其医药用途，本发明提供了如式(I)所示的海因类化合物或其药学上可接受的盐，该类化合物对PPARα和PPARδ具有强效激动作用，对PPARγ具有较好的选择性，且具有良好的药物代谢动力学性质。因此该类化合物或其药学上可接受的盐、前药、氘代化合物或溶剂化物可应用于制备PPARα/δ双重激动剂，用于预防或治疗PPARα和/或PPARδ介导的疾病。