Hollow spherical cefuroxime axetil preparation raw powder and preparation method thereof

The invention provides hollow spherical cefuroxime axetil preparation raw powder and a preparation method thereof. The method comprises the following steps: firstly, preparing a suspension: dissolving cefuroxime axetil crystal powder into anhydrous acetone, stirring and dissolving at 20-40 DEG C, clarifying, filtering to obtain a cefuroxime axetil acetone solution, and cooling to 0-5 DEG C; then adding cross-linked polyvinylpyrrolidone, microcrystalline cellulose, sodium carboxymethyl starch and polyvinylpyrrolidone, and stirring for 30-50 minutes to form a uniform suspension; and adding the obtained suspension into a centrifugal atomizer, and carrying out spray drying to obtain the hollow spherical cefuroxime axetil preparation raw powder. The particle size D70 of the product prepared by the method provided by the invention only has one interval, and the interval is 15-75 [mu] m; and the angle of repose is 40-47 degrees. Therefore, the particle size distribution of the raw powder is more uniform, and the lat