Application of transaminase in catalytic synthesis of lactam compound and synthesis method of lactam compound

The invention provides an application of transaminase in catalytic synthesis of a lactam compound and a synthesis method of the lactam compound. The transaminase is derived from an omega-transaminase mutant of Actinobacteria sp.. The synthesis method of the lactam compound comprises the following steps: dispersing a keto ester compound in a buffer solution, mixing the keto ester compound with an amino donor, and reacting the keto ester compound with the amino donor under the action of transaminase and an optional coenzyme to obtain the lactam compound. According to the technical scheme, the transaminase serves as the catalyst for synthesizing the lactam compound, the synthesis process is simple, reaction conditions are mild, few organic reagents are used, pollution is low, meanwhile, the conversion rate of a substrate and the purity of a product are greatly improved, the requirements of the pharmaceutical field can be met, and the application prospect is wide. A new thought is provided for artificially synthe