Preparation method of cefvimicin sodium

The invention discloses a preparation method of cefvimicin sodium, which belongs to the technical field of medicine, and comprises the following specific steps: reacting a starting material with sodium hydrosulfite paste to generate an intermediate A, reacting the obtained intermediate A with AE-active ester, treating a reaction solution, extracting with tetrahydrofuran, adding a sodium 2-ethylhexanoate solution to form a salt, filtering, and drying to obtain the cefvimicin sodium. And crystallizing to obtain a crude product of the cefvistar sodium, and finally recrystallizing to obtain a pure product of the cefvistar sodium. The method for preparing the cefvimicin sodium is simple to operate, easily available in raw materials, short in steps, low in cost, high in yield, high in purity and beneficial to industrial production. 本发明公开了一种头孢维星钠的制备方法，属于医药技术领域，具体步骤为由起始物料和保险粉糊状物反应生成中间体A，得到的中间体A和AE-活性酯反应，反应液处理后用四氢呋喃萃取，然后再加入2-乙基己酸钠溶液成盐，结晶得到头孢维星钠粗品，最后进行重结晶得到头孢维星钠纯品。本申请制备头孢维星钠的方法操作简单，原料易得，步骤简短，成本低，收率高，纯度高，利于工业生产。