RNA constructs and uses thereof

The present disclosure relates to RNA polynucleotides comprising a 5 'cap, a 5' UTR comprising a proximal sequence of the cap disclosed herein, and a sequence encoding a payload, Also disclosed herein are compositions and pharmaceutical articles comprising the RNA polynucleotides, and meth...

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Bibliographische Detailangaben
Hauptverfasser:	MUIK ALEXANDER, HEIN STEFAN, REINHOLZ, JOHANNES, VOGEL ANDREAS, SAHIN UGUR, WALZER KLAUS, TURECI OZLEM, BOROS GREGORY, CARRICO KEVIN, MAHINNEY ANDREW J, WITZEL SILKE, KUHN ARVID, GULER AYDIN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure relates to RNA polynucleotides comprising a 5 'cap, a 5' UTR comprising a proximal sequence of the cap disclosed herein, and a sequence encoding a payload, Also disclosed herein are compositions and pharmaceutical articles comprising the RNA polynucleotides, and methods of making and using the RNA polynucleotides. 本文公开涉及RNA多核苷酸，其包含5'帽，包含本文公开的帽近端序列的5'UTR和编码有效负载的序列。本文还公开包含所述RNA多核苷酸的组合物和药物制品，以及制备和使用所述RNA多核苷酸的方法。