Recommendation method and device for double-drug combined medication

The invention discloses a double-drug combined drug recommendation method. The method comprises the following steps: respectively acquiring first characterization parameters for characterizing each concentration combination of a to-be-detected combined drug and two single-component drugs under the i...

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Bibliographische Detailangaben
Hauptverfasser: GONG LIUPING, WANG JIA, LI SHENG, LU ZHENGHAO, HE CHUNHUA, YANG YUNXU, WANG HEYING, LONG CHUNMEI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a double-drug combined drug recommendation method. The method comprises the following steps: respectively acquiring first characterization parameters for characterizing each concentration combination of a to-be-detected combined drug and two single-component drugs under the independent action of corresponding concentrations; based on a preset first evaluation model and a preset second evaluation model, determining a second characterization parameter SLoewe and a third characterization parameter SBliss for characterizing the collaboration degree of each concentration combination; based on the first characterization parameter, the second characterization parameter and the third characterization parameter, a fourth characterization parameter for characterizing the synergistic degree of each drug combination is determined; acquiring a sixth characterization parameter for characterizing the sensitivity of the to-be-detected drug combination; and screening out the drug combination with the m