Detection method and application of lalocitaxel related substances

The invention discloses a detection method and application of related substances of lalocitaxel, related substances I1, I2, I3, I4, I5, I6, I7, I8, I9, I10 and I11 contained in lalocitaxel are controlled according to a synthesis process of lalocitaxel, the eleven related substances can be efficiently separated out at a time through specific high performance liquid chromatography detection conditions, and the detection method is high in specificity, good in durability, high in sensitivity and high in reliability. The method is high in sensitivity, and facilitates establishment of a research method for related substances of the lalotaxel and quality control of raw materials of the lalotaxel. 本发明公开了一种拉洛他赛有关物质的检测方法和应用，根据拉洛他赛合成工艺，对拉洛他赛中含有的有关物质I1、I2、I3、I4、I5、I6、I7、I8、I9、I10和I11进行控制，通过特定的高效液相色谱检测条件，可以实现一次性高效的分离出上述十一种有关物质，且专属性强，耐用性好，灵敏度高，便于建立拉洛他赛有关物质研究方法以及对拉洛他赛原料进行质量控制。