Mitomycin C prodrug as well as preparation method and application thereof

The invention provides a mitomycin C prodrug as well as a preparation method and application thereof. According to the mitomycin C prodrug disclosed by the invention, a 4-azido-2, 3, 5, 6-tetrafluorobenzyl alcohol structure is taken as a response group, and compared with a mitomycin C raw drug, the...

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Hauptverfasser: GENG JIN, YUE SIYUAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a mitomycin C prodrug as well as a preparation method and application thereof. According to the mitomycin C prodrug disclosed by the invention, a 4-azido-2, 3, 5, 6-tetrafluorobenzyl alcohol structure is taken as a response group, and compared with a mitomycin C raw drug, the prodrug can obtain semi-active targeting by virtue of the guidance of X rays in radiotherapy and chemotherapy combination, can relieve damage to normal cells of a whole body under the condition of not sacrificing a treatment effect, and can be used for preparing the mitomycin C prodrug. The adverse reaction of the patient is relieved; compared with an antibody coupling drug with the same targeting property, the semi-active targeting property of the mitomycin C prodrug is from X rays emitted by radiotherapy equipment, the mitomycin C prodrug can be directly and manually controlled, cancer cells do not need to have specific antigen properties, and the application range is wider; meanwhile, the mitomycin C prodrug dis