Lappaconitine hydrobromide transdermal patch and preparation method thereof

The invention belongs to the technical field of transdermal patches, and particularly relates to a lappaconitine hydrobromide transdermal patch and a preparation method thereof. The lappaconitine hydrobromide transdermal patch comprises a thin film backing layer, a medicine layer and a controlled release film layer which are sequentially arranged from top to bottom, the medicine layer comprises lappaconitine hydrobromide microcrystals and gel; the particle size of the lappaconitine hydrobromide microcrystal is 0.5-1 [mu] m; the gel comprises a gel matrix, a penetration enhancer, a preservative, a pH regulator and water. The lappaconitine hydrobromide transdermal patch provided by the invention can be beneficial to the constant-speed stable release of the lappaconitine hydrobromide. 本发明属于透皮贴剂技术领域，特别涉及一种氢溴酸高乌甲素透皮贴剂及其制备方法。其中，所述氢溴酸高乌甲素透皮贴剂包括由上至下依次设置的薄膜背衬层、药层、控释膜层；所述药层包括氢溴酸高乌甲素微晶和凝胶体；所述氢溴酸高乌甲素微晶的粒径为0.5～1μm；所述凝胶体包括凝胶基质、促渗剂、防腐剂、pH调节剂和水。本发明所提供的氢溴酸高乌甲素透皮贴剂可有利于氢溴酸高乌甲素的恒速稳定释放。