Methods of improving penetration of vitamin b3 compounds into skin

The invention discloses a method for improving penetration of a vitamin B3 compound into skin. The method involves a skin care regimen in which at least two skin care compositions are used in sequence to treat target skin portions for which skin health or appearance benefits are desired. The first composition applied to the skin is a low pH skin care composition containing a first concentration of a vitamin B3 compound. The second skin care composition applied to the skin is a conventional skin care composition containing a higher concentration of vitamin B3 compound than the first composition. When administered in a suitable sequence, the regimen results in an unexpectedly high flux of vitamin B3 into the skin. 本发明公开了一种改善维生素B3化合物渗透到皮肤中的方法。该方法涉及如下皮肤护理方案，在该皮肤护理方案中，按顺序使用至少两种皮肤护理组合物以处理期望皮肤健康或外观有益效果的目标皮肤部分。施用至皮肤的第一组合物是含有第一浓度的维生素B3化合物的低pH皮肤护理组合物。施用至皮肤的第二皮肤护理组合物是含有比第一组合物更高浓度的维生素B3化合物的常规皮肤护理组合物。当按合适的顺序施用时，该方案导致意外高的维生素B3通量进入皮肤。