Application of 1-methylnicotinamide in preparation of anti-vascular calcification medicine

The invention discloses an application of 1-methylnicotinamide in preparation of an anti-vascular calcification drug. The invention finds that the small molecule metabolite 1-methylnicotinamide has the effect of inhibiting vascular calcification and the progress thereof, and provides a new thought for the treatment of vascular calcification. The 1-methylnicotinamide has good drug safety and a strong vascular calcification inhibition effect, and can be used as a candidate drug for inhibiting vascular calcification. The 1-methylnicotinamide is a known small molecule metabolite, can be dissolved in water or DMSO, is good in stability, low in cytotoxicity and good in drug safety, and can be flexibly administrated in various modes such as oral administration and intravenous injection. 本发明公开了1-甲基烟酰胺在制备抗血管钙化药物中的应用。本发明发现小分子代谢物1-甲基烟酰胺具有抑制血管钙化及其进展的作用，为血管钙化的治疗提供了新的思路。1-甲基烟酰胺具有较好的药物安全性和较强的血管钙化抑制效果，可以作为抑制血管钙化的候选药物。而且1-甲基烟酰胺为已知的小分子代谢物，能溶于水或者DMSO，稳定性良好，细胞毒性低，药物安全性好，可通过口服和静脉注射等多种方式灵活给药。