Swine influenza A virus vaccines comprising nucleic acid constructs encoding specific viral lineage antigens

The invention relates to a nucleic acid construct. The present invention relates to a nucleic acid encoding a first swine influenza A virus (IAV-S) hemagglutinin (HA) antigen from the Scot/94 lineage of the strain A/swing/Italy/3033-1/2015 (H1N2) or an amino acid sequence having at least 85% sequence identity therewith and a second swine influenza A virus (IAV-S) hemagglutinin (HA) antigen from the Eurasian avian-like (EA) lineage of the strain A/swing/Italy/28762-3/2013 (H1N1) or an amino acid sequence having at least 90% sequence identity therewith; and to a nucleic acid construct encoding a first IAV-S HA antigen from the Gent/84 lineage of the strain A/swing/Italy/240849/2015 (H3N2) or an amino acid sequence having at least 95% sequence identity thereto and a second IAV-S HA antigen from the pandex 09 (pdm09) lineage of the strain A/swing/England/373/2010 (H1N1) or an amino acid sequence having at least 95% sequence identity thereto. In other embodiments, the invention relates to RNA replicon particles, i