1-aryl-1,8-naphthylidine-4-one derivative as type IV phosphodiesterase inhibitor

本发明提供了式(I)1-芳基-1，8-二氮杂萘-4-酮衍生物或其盐或溶剂化物，其中R#+[1]表示取代或未取代的芳基或取代或未取代的杂芳基，R#+[2]，R#+[3]，和R#+[4]独立地表示氢原子，取代或未取代的低级烷基，或卤原子；X表示基团NR#+[5]R#+[6]或基团OR#+[7]，其中R#+[5]和R#+[6]独立地表示氢原子，取代或未取代的低级烷基，取代或未取代的环烷基，取代或未取代的芳基，或取代或未取代的杂芳基，以及R#+[7]表示氢原子，取代或未取代的低级烷基，或取代或未取代的环烷基。本发明还提供了包含上述式(I)化合物作为有效成分的IV型磷酸二酯酶抑制剂。∴ A 1-aryl-1,8-naphthylidin-4-one derivative having the formula (I):wherein R1 indicates a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group,R2, R3, and R4 independently indicate a hydrogen atom, a substituted or unsubstituted lower alkyl group, or a halogen atom,X indicates a group NR5R6 or a group OR7, wherein R5 and R6 independently indicate a hydrogen a atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heteroaryl group, and R7 indicates a hydrogen atom, a substituted or unsubstituted lower alkyl group, or a substituted or unsubstituted cycloalkyl group or a salt or solvate thereof and a type IV phosphodiesterase inhibitor containing the same as an effective component.