De-symmetry method of prochiral dicarboxylate

The invention provides a desymmetry method of prochiral dicarboxylate. The prochiral dicarboxylate desymmetry method comprises the following steps: in a buffer solution, reacting a compound ii with an enzyme to obtain a compound iii; the prochiral dicarboxylate desymmetry method provided by the inve...

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Bibliographische Detailangaben
Hauptverfasser:	SUN FENGLAI, CHENG PENGFEI, SHI DONGSHENG, TAO HAIJUN, DAI KUANGCHU, ZHU JINGYANG, WANG XIAOWEI, ZHANG YA'NAN, YAO LIANBIN, WANG YOUCHU, MENG XIAO, JIN MING, XU XINGFU
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides a desymmetry method of prochiral dicarboxylate. The prochiral dicarboxylate desymmetry method comprises the following steps: in a buffer solution, reacting a compound ii with an enzyme to obtain a compound iii; the prochiral dicarboxylate desymmetry method provided by the invention is low in catalyst dosage, simple to operate and high in selectivity, and the yield of each step of synthesis route is relatively high. 本发明提供了一种潜手性二羧酸酯去对称化方法。本发明的潜手性二羧酸酯去对称化方法包括以下步骤：在缓冲溶液中，化合物ii与酶进行反应得到化合物iii。本申请的潜手性二羧酸酯去对称化方法催化剂用量低，操作简单，选择性高，且每步合成路线收率均较高。