Nucleic acid aptamer for targeting CD34 positive orbit fibroblasts and application of nucleic acid aptamer

The invention relates to a nucleic acid aptamer for targeting CD34 positive orbit fibroblasts, which is characterized in that the nucleotide sequences of the nucleic acid aptamer are as shown in SEQ ID NO: 1 to SEQ ID NO: 16; or the nucleic acid aptamer derivative with the same function is obtained by carrying out chemical modification, chemical labeling or basic group change on the basis of SEQ ID NO: 1-SEQ ID NO: 16. The nucleic acid aptamer provided by the invention has the advantages of high affinity, strong specificity, small molecular weight, good stability, simple synthesis, low cost, easy modification, no immunogenicity and the like, and can meet the requirements of rapid detection of thyroid-related ophthalmopathy at present. 本发明涉及一种靶向CD34阳性眼眶成纤维细胞的核酸适配体，其特征在于，所述核酸适配体的核苷酸序列如SEQ ID NO:1～SEQ ID NO:16所示；或者在SEQ ID NO:1～SEQ ID NO:16的基础上进行化学修饰、化学标记或碱基的改变后获得的具有相同功能的核酸适配体的衍生物。本发明所涉及的核酸适配体具有亲和性高、特异性强、分子量小、稳定性好、合成简单、成本低、易修饰、无免疫原性等优点，可满足目前甲状腺相关眼病快速检测的要求。