Novel coronavirus Omicron mutant strain specific antibody and application thereof

The invention relates to the technical field of antibodies, in particular to a novel coronavirus Omicron mutant strain specific antibody and application thereof. The invention provides an antibody specifically combined with a novel coronavirus Omicron mutant strain, the antibody can be used as a specific antibody for Omicron mutant strain antigen detection, is used for identifying a novel coronavirus vaccine designed for the Omicron mutant strain, and is used for quantitatively detecting the Spike RBD protein content expressed by the vaccine. The antibody can be used for quality control of novel coronavirus vaccines and immunogenicity detection of clinical and preclinical research, or can be used as a quality control antibody for detection of protective antibodies in serum after vaccination. 本发明涉及抗体技术领域，具体涉及新型冠状病毒Omicron突变株特异性抗体及其应用。本发明提供特异性结合新型冠状病毒Omicron突变株的抗体，该抗体可作为Omicron突变株抗原检测的特异性抗体，用于针对Omicron突变株设计的新型冠状病毒疫苗的鉴定，并对疫苗表达的Spike RBD蛋白含量进行定量检测，或用于新型冠状病毒疫苗的质控和临床及临床前研究的免疫原性检测，或作为接种疫苗后血清中保护性抗体检测的质控抗体。