PH/hydroperoxide/MMP9 time sequence response microsphere, biological carrier carrying exosome and application of pH/hydroperoxide/MMP9 time sequence response microsphere and biological carrier carrying exosome

The invention discloses a pH/hydrogen peroxide/MMP9 sequential response microsphere, a biological carrier carrying exosome and application, and relates to the technical field of drug carriers. According to the present invention, based on the protection effect of the SPARC high-expression regulatory T cell-derived exosome on the cardiac function and the levels of pH, H2O2 and MMP9 in the infarction region, the conjugated peptide, the pH/H2O2/MMP9 time sequence response microsphere and the biological carrier carrying the exosome are synthesized; firstly, acylhydrazone bonds are broken under an acidic condition, so that exosome and hydrogel raw materials are released; then, oxidizing Co < 2 + > into Co < 3 + > by utilizing H2O2 to form gel, and fixing the released exosome; and finally, under the hydrolysis of MMP9, the gel is gradually degraded and exosomes are released, so that the continuous and long-term protection effect on myocardium is achieved, and the heart function is improved. 本发明公开了一种pH/过氧化氢/MMP9时序性响应