SELF-ASSEMBLING PROTEIN NANOSTRUCTURES DISPLAYING PARAmyxoVIRUS AND/OR

Disclosed herein are nanostructures and uses thereof wherein the nanostructures comprise (a) a plurality of first components, each first component comprising a plurality of identical first polypeptides; (b) a plurality of second components, each second component comprising a plurality of identical second polypeptides, where the second polypeptides are different from the first polypeptides; wherein the plurality of first components non-covalently interact with the plurality of second components to form a nanostructure; and wherein the nanostructure exhibits a plurality of copies of one or more paramyxovirus and/or pneumovirus F proteins or antigen fragments thereof on an exterior of the nanostructure. 本文公开了纳米结构及其用途，其中该纳米结构包括(a)多个第一组件，每个第一组件包含多个相同的第一多肽；(b)多个第二组件，每个第二组件包含多个相同的第二多肽，其中所述第二多肽不同于所述第一多肽；其中多个第一组件与多个第二组件非共价地相互作用以形成纳米结构；并且其中所述纳米结构在所述纳米结构的外部上显示一种或多种副粘病毒和/或肺炎病毒F蛋白或其抗原片段的多个拷贝。