Gene nano-delivery system based on calcium-bound polysaccharide and calcium phosphate as well as preparation method and application of gene nano-delivery system

The invention relates to a gene nano-delivery system based on calcium-bound polysaccharide and calcium phosphate as well as a preparation method and application of the gene nano-delivery system. The present disclosure specifically relates to a gene nano-delivery system based on calcium-binding polys...

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Bibliographische Detailangaben
Hauptverfasser:	HUO MEIRONG, GONG WEIJIAO, YANG NAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a gene nano-delivery system based on calcium-bound polysaccharide and calcium phosphate as well as a preparation method and application of the gene nano-delivery system. The present disclosure specifically relates to a gene nano-delivery system based on calcium-binding polysaccharide and calcium phosphate, the delivery system is a nanoparticle comprising a shell and a core encapsulated by the shell, the core is formed by electrostatic condensation of calcium phosphate and a gene carrier, the shell comprises calcium-binding polysaccharide having calcium binding ability, and the calcium-binding polysaccharide has calcium binding ability. The calcium-bound polysaccharide and calcium form a complex through complexation. The invention also relates to a preparation method and application of the gene nano delivery system. The gene nano-delivery system disclosed by the invention is beneficial to delivery of the gene to a site where the gene plays a role, better plays a role in gene silencing