Effervescent tablet as well as preparation method and application thereof

The invention discloses an effervescent tablet as well as a preparation method and application thereof. The effervescent tablet comprises the following chemical components in percentage by weight: 5-25% of recombinant lysostaphin, 5-20% of hydroxypropyl methyl cellulose, 10-40% of sodium bicarbonate...

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Bibliographische Detailangaben
Hauptverfasser: LIANG GAN, LU YING, ZENG LINGHU, LI HUI, LIANG SHASHA, TAN ZHENGZHUN, ZHUGE YING, HUANG JIAN, HUANG RONGCHUN, YAN SHENGFEI, QIN GUANGSHENG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses an effervescent tablet as well as a preparation method and application thereof. The effervescent tablet comprises the following chemical components in percentage by weight: 5-25% of recombinant lysostaphin, 5-20% of hydroxypropyl methyl cellulose, 10-40% of sodium bicarbonate, 1-10% of lauryl sodium sulfate, 10-40% of citric acid, 1-15% of starch, 1-10% of a first additive and 0.05-0.2% of a second additive. The unique sterilization mechanism of the recombinant lysostaphin in the effervescent tablet is not easy to induce generation of drug-resistant strains, the diffusivity is relatively strong, the sterilization efficiency is high, the drug can be fully absorbed by cows, and the treatment time is shortened. 本发明公开了一种泡腾片、制备方法及其应用,其化学成分按重量百分比包括以下原料:重组溶葡萄球菌酶5-25%、羟丙基甲基纤维素5-20%、碳酸氢钠10-40%、十二烷基硫酸钠1-10%、柠檬酸10-40%、淀粉1-15%、第一添加剂1-10%、第二添加剂0.05-0.2%。该泡腾片中的重组溶葡萄球菌酶其独特的杀菌机制不易诱导产生耐药菌株,且扩散性较强,杀菌效率高,药物能被母牛充分吸收,降低治疗所需时间。