Chimeric antigen receptor with specificity for P95HER2 and application of chimeric antigen receptor

The present invention relates to a chimeric antigen receptor (CAR) capable of targeting cells expressing p95HER2. The invention also relates to a single-chain variable fragment (ScFv), an antigen binding domain, and an antibody or an antibody fragment thereof capable of binding to a p95HER2 antigen. The invention also relates to a cancer diagnosis method and a pharmaceutical composition for use in a method for preventing or treating cancer, the pharmaceutical composition comprising the CAR and/or the antigen binding domain or the antibody of the invention. 本发明涉及一种能够靶向表达p95HER2的细胞的嵌合抗原受体(CAR)。本发明还涉及一种单链可变片段(ScFv)、抗原结合结构域以及能够与p95HER2抗原结合的抗体或其抗体片段。本发明还涉及一种癌症诊断方法和在预防或治疗癌症的方法中的使用的药物组合物，所述药物组合物包括本发明的所述CAR和/或所述抗原结合结构域或所述抗体。