Compound with plasmin inhibitory activity as well as preparation method and application thereof

The invention provides a compound with plasmin inhibitory activity as well as a preparation method and application thereof, and relates to the field of medical chemistry. Specifically, the invention provides a compound as shown in a formula I and application thereof in the pharmaceutical field. In the formula I, X is CH or N; r1, R2 and R3 are respectively and independently selected from H, F, Cl, Br and I. The compound provided by the invention has excellent blood coagulation and hemostasis activity, long in-vivo half-life period, high blood concentration and exposure, good safety and good clinical application prospect. 本发明提供了一种纤溶酶抑制活性的化合物、其制备方法及应用，涉及医药化学领域。具体来说，本发明提供了式Ⅰ所示的化合物及其在制药领域中的应用。式Ⅰ中，X为CH或N；R1、R2、R3各自独立的选自H、F、Cl、Br、I。本发明提供的化合物具有优异的凝血、止血活性，在体内的半衰期长，血药浓度及暴露量高，安全性好，具有良好的临床应用前景。