Preparation method of canthaxanthin crystal

The invention discloses a canthaxanthin crystal preparation method, which comprises: adding a structure stabilizer and an inorganic salt into an organic solvent, uniformly mixing, adding a canthaxanthin crude product, carrying out an isomerization reaction, and separating out the canthaxanthin crystal after the reaction is finished. The canthaxanthin crystal D90 prepared by the process is less than 3 microns, the cis-form content is stably controlled at 1-10%, and the problems of crystal agglomeration, non-uniform emulsion particle size distribution and low preparation product embedding rate are effectively solved. 本发明公开了一种角黄素晶体的制备方法，将结构稳定剂、无机盐加入到有机溶剂中混合均匀，然后加入角黄素粗品，进行异构化反应，反应结束后析出角黄素晶体。采用该工艺制备所得角黄素晶体D90小于3μm，顺式体含量稳定控制在1-10%，有效解决晶体团聚，乳液粒径分布不均以及制剂产品包埋率低的问题。