Application of ginseng-radix aconiti lateralis preparata injection in medicine for treating vasculitis

The invention discloses an application of a ginseng-radix aconiti carmichaeli injection in a medicament for treating vasculitis. The ginseng-radix aconiti carmichaeli injection has a treatment effect on vasculitis mainly based on a leukotriene inflammation pathway. The ginseng-radix aconiti carmichaeli injection reduces the expression of cPLA2 to influence the yield of AA, also reduces the change of COX-1 and COX-2 to influence the yield of PG, adjusts the expression of TXAS and PGIS to play a dynamic balance role on TXA2/PGI2, and finally improves the hypercoagulable state of blood. And a new direction and thought are provided for clinical treatment of vasculitis. 本发明公开了参附注射液在治疗脉管炎药物中的应用，主要基于白三烯炎症通路对脉管炎起到治疗作用；参附注射液下调cPLA2的表达影响AA的产量，又通过下调COX-1和COX-2这两种酶的变化来影响PG产量，并调节TXAS和PGIS这两种酶的表达对TXA2/PGI2起动态平衡的作用，最终改善血液高凝状态。为脉管炎的临床治疗提供新的方向和思路。