Industrial production method of sodium hyaluronate oligosaccharide composition
The invention provides an industrial production method of a sodium hyaluronate oligosaccharide composition, which comprises the following steps: carrying out enzymolysis reaction on a macromolecular or medium molecular sodium hyaluronate raw material in the presence of leech type hyaluronidase to ob...
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| creator | PAN SHANGSHU XU YONGGANG WANG JUNZHI CAI XUEBO |
| description | The invention provides an industrial production method of a sodium hyaluronate oligosaccharide composition, which comprises the following steps: carrying out enzymolysis reaction on a macromolecular or medium molecular sodium hyaluronate raw material in the presence of leech type hyaluronidase to obtain a mixture containing the sodium hyaluronate oligosaccharide composition; the preparation method comprises the following steps: preparing a sodium hyaluronate oligosaccharide composition with the dynamic viscosity of 20-30cP and the average molecular weight of 850-1050Da, filtering by adopting a nanofiltration membrane with the molecular weight cut-off of 25KD-35KD, only needing a one-step low-temperature nanofiltration process, not needing filtering sterilization and activated carbon adsorption again, and directly spray-drying the filtrate, thereby obtaining a fine product of the sodium hyaluronate oligosaccharide composition with the dynamic viscosity of 20-30cP and the average molecular weight of 850-1050Da. |
| format | Patent |
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the preparation method comprises the following steps: preparing a sodium hyaluronate oligosaccharide composition with the dynamic viscosity of 20-30cP and the average molecular weight of 850-1050Da, filtering by adopting a nanofiltration membrane with the molecular weight cut-off of 25KD-35KD, only needing a one-step low-temperature nanofiltration process, not needing filtering sterilization and activated carbon adsorption again, and directly spray-drying the filtrate, thereby obtaining a fine product of the sodium hyaluronate oligosaccharide composition with the dynamic viscosity of 20-30cP and the average molecular weight of 850-1050Da.</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS BASED THEREON ; DERIVATIVES THEREOF ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; 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the preparation method comprises the following steps: preparing a sodium hyaluronate oligosaccharide composition with the dynamic viscosity of 20-30cP and the average molecular weight of 850-1050Da, filtering by adopting a nanofiltration membrane with the molecular weight cut-off of 25KD-35KD, only needing a one-step low-temperature nanofiltration process, not needing filtering sterilization and activated carbon adsorption again, and directly spray-drying the filtrate, thereby obtaining a fine product of the sodium hyaluronate oligosaccharide composition with the dynamic viscosity of 20-30cP and the average molecular weight of 850-1050Da.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES SPIRITS SUGARS THEIR PREPARATION OR CHEMICAL WORKING-UP VINEGAR WINE |
| title | Industrial production method of sodium hyaluronate oligosaccharide composition |
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