Industrial production method of sodium hyaluronate oligosaccharide composition

Industrial production method of sodium hyaluronate oligosaccharide composition

The invention provides an industrial production method of a sodium hyaluronate oligosaccharide composition, which comprises the following steps: carrying out enzymolysis reaction on a macromolecular or medium molecular sodium hyaluronate raw material in the presence of leech type hyaluronidase to ob...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PAN SHANGSHU, XU YONGGANG, WANG JUNZHI, CAI XUEBO
Format: Patent
Sprache:chi ; eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
SPIRITS
SUGARS
THEIR PREPARATION OR CHEMICAL WORKING-UP
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The invention provides an industrial production method of a sodium hyaluronate oligosaccharide composition, which comprises the following steps: carrying out enzymolysis reaction on a macromolecular or medium molecular sodium hyaluronate raw material in the presence of leech type hyaluronidase to obtain a mixture containing the sodium hyaluronate oligosaccharide composition; the preparation method comprises the following steps: preparing a sodium hyaluronate oligosaccharide composition with the dynamic viscosity of 20-30cP and the average molecular weight of 850-1050Da, filtering by adopting a nanofiltration membrane with the molecular weight cut-off of 25KD-35KD, only needing a one-step low-temperature nanofiltration process, not needing filtering sterilization and activated carbon adsorption again, and directly spray-drying the filtrate, thereby obtaining a fine product of the sodium hyaluronate oligosaccharide composition with the dynamic viscosity of 20-30cP and the average molecular weight of 850-1050Da.