Preparation method of o-pyrrolidinyl benzamide compound

The invention provides a preparation method of an o-pyrrolidinyl benzamide compound. According to the method, o-aminobenzoate compounds are adopted as raw materials, o-pyrrolidinyl benzoic acid compounds are obtained through a substitution reaction and a hydrolysis reaction, or corresponding acyl chloride compounds are further generated, and then the acyl chloride compounds and corresponding amine compounds are subjected to condensation to obtain the o-pyrrolidinyl benzamide compounds. The method provided by the invention has the advantages of mild reaction conditions, short route, large-scale synthesis and low production cost. In the preparation process, column chromatography purification is not needed, a high-purity target product can be obtained only through recrystallization, and the method is suitable for large-scale industrial production. 本发明提供了一种邻吡咯烷基苯甲酰胺类化合物的制备方法。该方法采用邻氨基苯甲酸酯类化合物为原料，经取代反应、水解反应得到邻吡咯烷基苯甲酸类化合物，或进一步生成相应的酰氯化合物，随后与相应的胺类化合物进行缩合得到邻吡咯烷基苯甲酰胺类化合物。本发明的方法具有反应条件温和、路线简短、能大量合成以及生产成本低的优点。制备过程中，无需柱层析纯化