Microfluidic preparation method of aluminum salt vaccine adjuvant

The invention discloses a microfluidics preparation method of an aluminum salt vaccine adjuvant. The microfluidics preparation method comprises the following steps: fully mixing and reacting a prepared solution in a microreactor; enabling the prepared solution to continuously and circularly flow through a micro-mixer by utilizing a driving pump, and limiting the agglomeration of the aluminum salt by utilizing a shearing effect; the size of the shearing force is controlled through the flow velocity, so that the particle size is regulated; a heating device and a temperature control device are arranged on the container and the micro-mixer at the same time, and the product is heated in the cyclic shearing process. The aluminum salt adjuvant prepared by the method is more controllable in particle size, good in uniformity and small in batch-to-batch difference. 本发明公开了一种铝盐疫苗佐剂的微流控制备方法，包括如下步骤：使用微反应器将配制好的溶液在其中进行充分混合、反应；利用驱动泵将制备好的溶液不断循环流经一个微混合器，利用剪切作用限制铝盐的团聚；剪切力的大小通过流速进行控制，进而调控粒径大小；在容器和微混合器上同时配有加热和温控装置，在循环剪切过程中对产物进行加热。