RARA agonists for treatment of AML and MDS

The present application relates to RARA agonists for the treatment of AML and MDS. Described herein are methods of defining a population of cells that are sensitive to a RARA agonist and identifying a population of patients that would benefit from treatment with a RARA agonist. The method may includ...

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Bibliographische Detailangaben
Hauptverfasser:	MCKEOWN MICHAEL R, LEE ERIC PAUL, FRITZ CHRISTOPH, EATON MATTHEW LUCAS, FIORE CHRISTOPHER
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present application relates to RARA agonists for the treatment of AML and MDS. Described herein are methods of defining a population of cells that are sensitive to a RARA agonist and identifying a population of patients that would benefit from treatment with a RARA agonist. The method may include administering a RARA agonist to a population of patients. 本申请涉及用于治疗AML和MDS的RARA激动剂。本文描述了限定对RARA激动剂敏感的细胞群体并鉴定将受益于用RARA激动剂治疗的患者群体的方法。所述方法可包括向患者群体施用RARA激动剂。