Echinococcus granulosus and echinococcus canadensis bivalent subunit vaccine and preparation method thereof

The invention discloses a bivalent subunit vaccine of echinococcus granulosus and echinococcus canadensis and a preparation method of the bivalent subunit vaccine of echinococcus granulosus and echinococcus canadensis. The bivalent subunit vaccine comprises an immunogen dEG95/dEC95 antigen protein a...

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Hauptverfasser: ZHONG CONGHAO, DU XIANGYUE, ZHANG ZHEN, NIE DONGSHENG, WANG JIANGHUI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a bivalent subunit vaccine of echinococcus granulosus and echinococcus canadensis and a preparation method of the bivalent subunit vaccine of echinococcus granulosus and echinococcus canadensis. The bivalent subunit vaccine comprises an immunogen dEG95/dEC95 antigen protein and a pharmaceutically acceptable carrier, wherein the amino acid sequence of the dEG95 protein is as shown in SEQ ID No. 1; the amino acid sequence of the dEC95 protein is as shown in SEQ ID No. 2. At present, no vaccine capable of resisting echinococcus granulosus infection and echinococcus Canadensis infection at the same time exists, the dEG95-dEC95 heterodimer protein is adopted as an antigen, and the prepared biunit vaccine capable of resisting echinococcus granulosus and echinococcus Canadensis is low in production cost and simple in production process; the antigen can prevent infection of echinococcus granulosus and echinococcus canadensis at the same time, and has the advantages of being safe, efficient, lo