Elagic acid nanosuspension with high solubility and antioxidant activity and application of ellagic acid nanosuspension in oral and external preparations and cosmetics

Elagic acid is recognized as a whitening agent, an antioxidant and a nutritional agent, but the extremely low solubility greatly limits its application. In order to solve the problem, the invention provides the ellagic acid nanosuspension, the ellagic acid nanosuspension comprises ellagic acid nanop...

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Bibliographische Detailangaben
Hauptverfasser: GU WEI, JI JING, WANG YIWEI, QI SHUYANG, CHENG JIANMING
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:Elagic acid is recognized as a whitening agent, an antioxidant and a nutritional agent, but the extremely low solubility greatly limits its application. In order to solve the problem, the invention provides the ellagic acid nanosuspension, the ellagic acid nanosuspension comprises ellagic acid nanoparticles with the particle size of 100-1000 nm, the ellagic acid nanoparticles are composed of ellagic acid and a preparation solvent, and the preparation solvent is preferably selected from water, ethanol, propylene glycol, butanediol, pentanediol or a mixed solvent of the water, the ethanol, the propylene glycol, the butanediol and the pentanediol; according to the preferable scheme, the supersaturated ellagic acid solution is prepared through an ultrasonic process, the feeding amount of ellagic acid during preparation is larger than or equal to 20 mg/mL, and the ultrasonic temperature is larger than or equal to 35 DEG C. According to the invention, auxiliary materials are not required to be added, a complex prep