2, 3-dihydroimidazo [1, 2-c] quinazoline substituted derivatives

The present invention relates to 2, 3-dihydroimidazo [1, 2-c] quinazoline substituted derivatives useful in the treatment of hyperproliferative diseases and angiogenesis-related diseases. The present invention relates to novel 2, 3-dihydroimidazo [1, 2-c] quinazolines, pharmaceutical compositions comprising these compounds and the use of these compounds or compositions for the inhibition of phosphatidylinositol-3-kinase (PI3K) and the treatment of diseases associated with phosphatidylinositol-3-kinase (PI3K) activity, alone or in combination with other active ingredients, in particular to treat hyperproliferative and/or angiogenic diseases. 本发明涉及用于治疗过度增殖疾病和血管发生相关性疾病的2,3-二氢咪唑并[1,2-c]喹唑啉取代衍生物。本发明涉及新的2,3-二氢咪唑并[1,2-c]喹唑啉类化合物、包含这些化合物的药物组合物以及将这些化合物或组合物单独作为药剂或与其它活性成分组合用于抑制磷脂酰肌醇-3-激酶(PI3K)和治疗与磷脂酰肌醇-3-激酶(PI3K)活性相关的疾病,特别是治疗过度增殖疾病和/或血管发生疾病。