Continuous metabolism monitor for gas sterilization

A metabolic analyte sensor comprising: a substrate having an electrically conductive surface; an interference layer, the interference layer being on the conductive surface; the enzyme layer is arranged on the interference layer; and a glucose confinement layer, the glucose confinement layer being on the enzyme layer. The interference layer or the enzyme layer is configured such that the metabolic analyte sensor has improved performance characteristics after sterilization compared to before sterilization. A packaged continuous metabolism monitor comprises: a sealed container; a metabolic sensor in the sealed container to be inserted into a patient after the metabolic sensor is removed from the sealed container, the metabolic sensor comprising an electrically conductive surface and an enzyme layer; an electronic operating circuit in the sealed container and coupled to the metabolism sensor; and sterilizing the residue of the gas in the metabolic sensor. The sealed container, the metabolism sensor, and the elect