Method for preparing (R)-2-(2, 5-difluorophenyl) pyrrolidine

Method for preparing (R)-2-(2, 5-difluorophenyl) pyrrolidine

The invention discloses a synthesis method of (R)-2-(2, 5-difluorophenyl) pyrrolidine, which is characterized by comprising the following reaction steps: a, reacting a compound 1, 4-difluorobenzene, tert-butyl lithium and N-Boc-2-pyrrolidone to prepare a compound IX; and b, preparing the compound I...

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1. Verfasser: CHEN ZECONG
Format: Patent
Sprache:chi ; eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The invention discloses a synthesis method of (R)-2-(2, 5-difluorophenyl) pyrrolidine, which is characterized by comprising the following reaction steps: a, reacting a compound 1, 4-difluorobenzene, tert-butyl lithium and N-Boc-2-pyrrolidone to prepare a compound IX; and b, preparing the compound I from the compound IX under the catalysis of imine reductase. The invention relates to a method for preparing (R)-2-(2, 5-difluorophenyl) pyrrolidine by using 1, 4-difluorobenzene as a raw material and using an imine reductase catalysis mode, and the method is simple, high in efficiency, environment-friendly and low in cost. 本发明公开了一种(R)-2-(2,5-二氟苯基)吡咯烷的合成方法，其特征在于，包括以下反应步骤：a、化合物1,4-二氟苯、叔丁基锂、N-Boc-2-吡咯烷酮反应制备得到化合物IX；b、化合物IX在亚胺还原酶催化下制备得到化合物I。使用1,4-二氟苯作为原料，使用亚胺还原酶催化方式制备(R)-2-(2,5-二氟苯基)吡咯烷的方法，这种方法简单，效率高，环保，成本低。