NOVEL COMPOUNDS USEFUL AS STING AGONISTS AND USES THEREOF
Compounds of general formula I, II or III, and pharmaceutically acceptable salts, esters, stereoisomers, tautomers, isotope derivatives or prodrugs thereof, useful as inducers of type I interferon production, in particular as STING agonists are provided. Also provided are compound-linker constructs,...
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| creator | YE YANG LI XIUWEI YANG GUIQUN YAN FASHUN LONG WEI WANG YANPING |
| description | Compounds of general formula I, II or III, and pharmaceutically acceptable salts, esters, stereoisomers, tautomers, isotope derivatives or prodrugs thereof, useful as inducers of type I interferon production, in particular as STING agonists are provided. Also provided are compound-linker constructs, conjugates, and methods of preparation, compositions, and uses of these compounds.
提供了可用作I型干扰素产生的诱导剂，特别是作为STING激动剂的通式I、II或III的化合物及其药学上可接受的盐、酯、立体异构体、互变异构体、同位素衍生物或前药。还提供了化合物-连接子构建体、缀合物以及这些化合物的制备方法、组合物和用途。 |
| format | Patent |
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提供了可用作I型干扰素产生的诱导剂，特别是作为STING激动剂的通式I、II或III的化合物及其药学上可接受的盐、酯、立体异构体、互变异构体、同位素衍生物或前药。还提供了化合物-连接子构建体、缀合物以及这些化合物的制备方法、组合物和用途。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NOVEL COMPOUNDS USEFUL AS STING AGONISTS AND USES THEREOF |
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