Compound as well as preparation method and application thereof

The invention relates to a compound as well as a preparation method and application thereof, and belongs to the field of medicinal chemistry. The compound is a precursor compound of celecoxib. The compound is high in solubility and high in metabolism speed, can be rapidly metabolized into an active...

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Hauptverfasser: WANG ZHONGQING, SUN JINGWEI, ZENG JIEBIN, TIAN KAI, LUAN BAOLEI, FANG JINTAO, LI CHUNMING, TANG WENJIE, LUO JIJIA, ZHONG ZIYI, FENG ZIJUN, KOU JINGPING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a compound as well as a preparation method and application thereof, and belongs to the field of medicinal chemistry. The compound is a precursor compound of celecoxib. The compound is high in solubility and high in metabolism speed, can be rapidly metabolized into an active substance, and improves bioavailability and medication compliance. The compound can be used for preparing a medicament for treating traumatic or non-traumatic pain or inflammation. 本发明涉及一种化合物及其制备方法和用途,属于药物化学领域。所述化合物为塞来昔布的前体化合物。所述化合物溶解度高,代谢速度快,可快速代谢为活性物质,提高生物利用度,提高用药顺应性。所述化合物可用于制备用于治疗创伤或非创伤的疼痛或炎症的药物。