Swine influenza A virus vaccine comprising two different RNA replicon particles

The present invention relates to an immunogenic composition comprising first and second RNA replicon particles. The first RNA replicon particle comprises a nucleic acid construct comprising first and second nucleic acid sequences encoding first and second hemagglutinin (HA) antigens of swine influenza A virus (IAV-S). In some embodiments, the first HA antigen is an HA antigen of the A/swing/Gent/1/1984-like H3N2 (Gent/84) lineage, and the second HA antigen is an HA antigen of the A (H1N1) pdm09 (pdm09) lineage. The second RNA replicon particle comprises a nucleic acid construct comprising third and fourth nucleic acid sequences encoding third and fourth HA antigens of IAV-S. The third HA antigen is the HA antigen of the A/swing/Scotland/410440/1994-like H1huN2 (Scot/94) lineage, and the fourth HA antigen is the HA antigen of the Eurasian avian-like H1avN1 (EA) lineage. In other embodiments, the present invention relates to vaccines useful against influenza A virus infection and comprising an immunogenic compo